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ea0081yi12 | Young Investigator Awards | ECE2022

Role of the transcription factor HHEX in inner adrenal cortex homeostasis and response to progesterone signaling

Dumontet Typhanie , Basham Kaitlin , Lerario Antonio , Bothou Christina , Brixius Bjoern , Turcu Adina F , Beuschlein Felix , Hammer Gary D

The adrenal glands serve as central organs of the endocrine system by producing steroid hormone essential for organismal homeostasis. Mechanisms ensuring proper adrenal homeostasis and function are therefore crucial for maintaining human life. ACTH, released by the pituitary corticotrope, is required for the differentiation of the inner part of the adrenal cortex (the zona fasciculata) and the resultant stimulation of cortisol production. Perturbation of ACTH signaling can lea...

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ea0081oc2.2 | Oral Communications 2: Adrenal and Cardiovascular Endocrinology 1 | ECE2022

Loss of SUMO-specific protease 2 leads to adrenal insufficiency limited to glucocorticoids

Dufour Damien , Dumontet Typhanie , Sahut-Barnola Isabelle , Onzon Meline , Pussard Eric , Wilmouth Jr James , Olabe Julie , Levasseur Adrien , Bossis Guillaume , Yeh Edward , Val Pierre , Martinez Antoine , Anne-Marie Lefrancois-Martinez

The adrenal gland produces corticosteroids essential for hydromineral and metabolic homeostasis. It is organised, in mice, in two concentric layers. The zona glomerulosa (zG) and fasciculate (zF), renewed from progenitors located in the capsular periphery. Centripetal renewal and maintenance of cortical zonation are dependant of a balance between WNT/β-catenin and ACTH/PKA signalling pathways. They provide recruitment and consecutive differentiation of progenitors into zG...

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Endocrine Abstracts

Role of the transcription factor HHEX in inner adrenal cortex homeostasis and response to progesterone signaling

Loss of SUMO-specific protease 2 leads to adrenal insufficiency limited to glucocorticoids

BiosciAbstracts